What Is VDR?

VDR is a gene which encodes for a protein that acts as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with lower bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the reciprocal and temporal pattern of off- and on- occupancy of the VDRE by two components, and it is influenced by chromosomal locations and by binding preferences for specific hormones. Microarray studies of human cells show that more than 100 genes are enriched with VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository of data and documents related to legal, business transactions or proceedings with restrictions on viewing or downloading. It utilizes a central computer as well as an extranet which is a restricted access Internet connection that allows users to access the internet at set times.

VDRs are most commonly used by investment banks and businesses involved in mergers or acquisitions. They require https://www.gescheftmarketing.de/2021/09/01/how-much-icloud-storage-do-you-really-need/ a secure platform for sharing information with investors or buyers in a transparent way, and due diligence can require huge amounts of information. Life science companies also utilize VDRs to keep everything from clinical trial results to HIPAA documentation.